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Transcriptomic profiling of microglia and astrocytes throughout aging

1 Apr 2020

Abstract excerpt

BACKGROUND: Activation of microglia and astrocytes, a prominent hallmark of both aging and Alzheimer's disease (AD), has been suggested to contribute to aging and AD progression, but the underlying cellular and molecular mechanisms are largely unknown. METHODS: We performed RNA-seq analyses on microglia and astrocytes freshly isolated from wild-type and APP-PS1 (AD) mouse brains at five time points to elucidate...

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PMID: 32238175
DOI: 10.1186/s12974-020-01774-9

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