Article

Loss of region-specific glial homeostatic signature in prion diseases

2019-11-07

Abstract excerpt

<title>Abstract</title> <p>Background Chronic neuroinflammation is recognized as a major neuropathological hallmark in a broad spectrum of neurodegenerative diseases including Alzheimer’s, Parkinson’s, Frontal Temporal Dementia, Amyotrophic Lateral Sclerosis, and prion diseases. Both microglia and astrocytes exhibit region-specific homeostatic transcriptional identities, which under chronic neurodegeneration, tra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b72aa480-ef6d-54b1-8434-7391fba7e5ce
DOI: 10.21203/rs.2.17016/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of region-specific glial homeostatic signature in prion diseasesDOI 10.21203/rs.2.17016/v1Read

Loss of region-specific glial homeostatic signature in prion diseasesSemantic proximity Read

RNA-seq and network analysis reveal unique glial gene expression signatures during prion infectionSemantic proximity Read

Region-specific homeostatic identity of astrocytes is essential for defining their reactive phenotypes following pathological insultsSemantic proximity Read

The degree of astrocyte activation is predictive of the incubation time to prion diseaseSemantic proximity Read

Microglia-specific NF-κB signaling is a critical regulator of prion-induced glial inflammation and neuronal lossSemantic proximity Read

Core Activation Program and Selective Regional Responsiveness of Microglia in Aging and ParabiosisSemantic proximity Read

Microglial brain region-dependent diversity and selective regional sensitivities to aging.Semantic proximity Read

Regional Differences in Neuroinflammation-Associated Gene Expression in the Brain of Sporadic Creutzfeldt–Jakob Disease PatientsSemantic proximity Read

Uncovering Plaque-Glia Niches in Human Alzheimer’s Disease Brains Using Spatial TranscriptomicsSemantic proximity Read

Absence of Apolipoprotein E is associated with exacerbation of prion pathology and promotes microglial neurodegenerative phenotype.Semantic proximity Read

Neuroinflammation characterizes the earliest changes in Alzheimer’s disease pathology and associated subjective cognitive impairment in adult hydrocephalus biopsiesSemantic proximity Read

A core transcriptional signature of human microglia: derivation and utility in describing region-dependent alterations associated with Alzheimer's diseaseSemantic proximity Read