Article
Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution.
Cell reports - 10 Oct 2017
Mathys Hansruedi, Adaikkan Chinnakkaruppan, Gao Fan, Young Jennie Z, Manet Elodie, Hemberg Martin, De Jager Philip L, Ransohoff Richard M, Regev Aviv, Tsai Li-Huei
Abstract excerpt
Microglia, the tissue-resident macrophages in the brain, are damage sensors that react to nearly any perturbation, including neurodegenerative diseases such as Alzheimer's disease (AD). Here, using single-cell RNA sequencing, we determined the transcriptome of more than 1,600 individual microglia cells isolated from the hippocampus of a mouse model of severe neurodegeneration with AD-like phenotypes and of...
Topics
- Alzheimer Disease
- Animals
- Brain
- Cells, Cultured
- Gene Expression Profiling
- Interferon Type I
- Interferon-gamma
- Macrophage Activation
- Macrophages
- Mice
- Microglia