Article
Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure (London, England : 1993) - 7 Jul 2020
Lambert Abigail R, Hallinan Jazmine P, Werther Rachel, Głów Dawid, Stoddard Barry L
Abstract excerpt
The redesign of a macromolecular binding interface and corresponding alteration of recognition specificity is a challenging endeavor that remains recalcitrant to computational approaches. This is particularly true for the redesign of DNA binding specificity, which is highly dependent upon bending, hydrogen bonds, electrostatic contacts, and the presence of solvent and counterions throughout the molecular...
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