Mutability of DNA polymerase I: implications for the creation of mutant DNA polymerases.

doi:10.1016/j.dnarep.2005.09.006

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Article

Mutability of DNA polymerase I: implications for the creation of mutant DNA polymerases.

DNA repair - 8 Dec 2005

Loh Ern, Loeb Lawrence A

Abstract excerpt

DNA polymerases of the Family A catalyze the addition of deoxynucleotides to a primer with high efficiency, processivity, and selectivity-properties that are critical to their function both in nature and in the laboratory. These polymerases tolerate many amino acid substitutions, even in regions that are evolutionarily conserved. This tolerance can be exploited to create DNA polymerases with novel properties and...

Topics

Amino Acid Motifs
Amino Acid Sequence
Animals
Conserved Sequence
DNA Polymerase I
Humans
Molecular Sequence Data
Mutation
Protein Structure, Tertiary
Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 16230053
DOI: 10.1016/j.dnarep.2005.09.006

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