Article
Mutagenic dissection of the sequence determinants of protein folding, recognition, and machine function.
Protein science : a publication of the Protein Society - 1 Nov 2013
Sauer Robert T
Abstract excerpt
Understanding the relationship between the amino-acid sequence of a protein and its ability to fold and to function is one of the major challenges of protein science. Here, cases are reviewed in which mutagenesis, biochemistry, structure determination, protein engineering, and single-molecule biophysics have illuminated the sequence determinants of folding, binding specificity, and biological function for...
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