Article
Selection of mutations for increased protein stability.
Current opinion in biotechnology - 1 Aug 2002
van den Burg Bertus, Eijsink Vincent G H
Abstract excerpt
There are many ways to select mutations that increase the stability of proteins, including rational design, functional screening of randomly generated mutant libraries, and comparison of naturally occurring homologous proteins. The protein engineer's toolbox is expanding and the number of successful examples of engineered protein stability is increasing. Still, the selection of thermostable mutations is not a...
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