DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping.

Abstract excerpt

Circadian molecular oscillation is generated by a transcription/translation-based feedback loop in which CRY proteins play critical roles as potent inhibitors for E-box-dependent clock gene expression. Although CRY2 undergoes rhythmic phosphorylation in its C-terminal tail, structurally distinct from the CRY1 tail, little is understood about how protein kinase(s) controls the CRY2-specific phosphorylation and...

Topics

• Animals
• Biological Clocks
• Cells, Cultured
• Circadian Rhythm
• Cryptochromes
• Glycogen Synthase Kinase 3
• Glycogen Synthase Kinase 3 beta
• Mice
• Mice, Inbred C57BL
• Mice, Knockout