Article
A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock.
Genes & development - 15 Mar 2009
Maier Bert, Wendt Sabrina, Vanselow Jens T, Wallach Thomas, Reischl Silke, Oehmke Stefanie, Schlosser Andreas, Kramer Achim
Abstract excerpt
Post-translational processes are essential for the generation and dynamics of mammalian circadian rhythms. In particular, phosphorylation of the key circadian protein PER2 precisely controls the period and phase of circadian oscillations. However, the mechanisms underlying that control are poorly understood. Here, we identified in a high-throughput RNAi-based genetic screen casein kinase 2 (CK2) as a...
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