Article
In vivo role of phosphorylation of cryptochrome 2 in the mouse circadian clock.
Molecular and cellular biology - 1 Dec 2014
Hirano Arisa, Kurabayashi Nobuhiro, Nakagawa Tomoki, Shioi Go, Todo Takeshi, Hirota Tsuyoshi, Fukada Yoshitaka
Abstract excerpt
The circadian clock is finely regulated by posttranslational modifications of clock components. Mouse CRY2, a critical player in the mammalian clock, is phosphorylated at Ser557 for proteasome-mediated degradation, but its in vivo role in circadian organization was not revealed. Here, we generated CRY2(S557A) mutant mice, in which Ser557 phosphorylation is specifically abolished. The mutation lengthened...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.