Article
The structure of helical lipoprotein lipase reveals an unexpected twist in lipase storage.
Proceedings of the National Academy of Sciences of the United States of America - 12 May 2020
Gunn Kathryn H, Roberts Benjamin S, Wang Fengbin, Strauss Joshua D, Borgnia Mario J, Egelman Edward H, Neher Saskia B
Abstract excerpt
Lipases are enzymes necessary for the proper distribution and utilization of lipids in the human body. Lipoprotein lipase (LPL) is active in capillaries, where it plays a crucial role in preventing dyslipidemia by hydrolyzing triglycerides from packaged lipoproteins. Thirty years ago, the existence of a condensed and inactive LPL oligomer was proposed. Although recent work has shed light on the structure of the...
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