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Article

Lipase maturation factor 1: a lipase chaperone involved in lipid metabolism.

Biochimica et biophysica acta - 1 May 2012

Péterfy Miklós

Abstract excerpt

Mutations in lipase maturation factor 1 (LMF1) are associated with severe hypertriglyceridemia in mice and human subjects. The underlying cause is impaired lipid clearance due to lipase deficiency. LMF1 is a chaperone of the endoplasmic reticulum (ER) and it is critically required for the post-translational activation of three vascular lipases: lipoprotein lipase (LPL), hepatic lipase (HL) and endothelial lipase...

Read the complete abstract on PubMed

Topics

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Share to Gene Expression Regulation
Share to Lipase
Share to Lipid Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipid Metabolism, Inborn Errors

Share to Lipoprotein Lipase

Share to Membrane Proteins

Share to Molecular Chaperones

Share to Protein Multimerization

Source

Open in PubMed Open full text

Identifiers

PMID: 22063272
DOI: 10.1016/j.bbalip.2011.10.006
PMCID: PMC3288453

Genes

LMF1
LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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