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Article

Heparin-binding defective lipoprotein lipase is unstable and causes abnormalities in lipid delivery to tissues.

The Journal of clinical investigation - 1 May 2001

Lutz E P, Merkel M, Kako Y, Melford K, Radner H, Breslow J L, Bensadoun A, Goldberg I J

Abstract excerpt

Lipoprotein lipase (LpL) binding to heparan sulfate proteoglycans (HSPGs) is hypothesized to stabilize the enzyme, localize LpL in specific capillary beds, and route lipoprotein lipids to the underlying tissues. To test these hypotheses in vivo, we created mice expressing a human LpL minigene (hLpL(HBM)) carrying a mutated heparin-binding site. Three basic amino acids in the carboxyl terminal region of LpL were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11342582
DOI: 10.1172/JCI11774
PMCID: PMC209279

Genes

HBM
LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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