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Article

A plug release mechanism for membrane permeation by MLKL.

Structure (London, England : 1993) - 7 Oct 2014

Su Lijing, Quade Bradley, Wang Huayi, Sun Liming, Wang Xiaodong, Rizo Josep

Abstract excerpt

MLKL is crucial for necroptosis, permeabilizing membranes through its N-terminal region upon phosphorylation of its kinase-like domain by RIP3. However, the mechanism underlying membrane permeabilization is unknown. The solution structure of the MLKL N-terminal region determined by nuclear magnetic resonance spectroscopy reveals a four-helix bundle with an additional helix at the top that is likely key for MLKL...

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Share to Cell Membrane
Share to Models, Molecular
Share to Nuclear Magnetic Resonance, Biomolecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Permeability

Share to Phosphorylation

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Share to Spectrometry, Fluorescence

Source

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Identifiers

PMID: 25220470
DOI: 10.1016/j.str.2014.07.014
PMCID: PMC4192069

Genes

MLKL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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