Article
Direct observation of Thermomyces lanuginosus lipase diffusional states by Single Particle Tracking and their remodeling by mutations and inhibition.
Scientific reports - 7 Nov 2019
Bohr Søren S-R, Lund Philip M, Kallenbach Amalie S, Pinholt Henrik, Thomsen Johannes, Iversen Lars, Svendsen Allan, Christensen Sune M, Hatzakis Nikos S
Abstract excerpt
Lipases are interfacially activated enzymes that catalyze the hydrolysis of ester bonds and constitute prime candidates for industrial and biotechnological applications ranging from detergent industry, to chiral organic synthesis. As a result, there is an incentive to understand the mechanisms underlying lipase activity at the molecular level, so as to be able to design new lipase variants with tailor-made...
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