Article

The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding

2022-04-22

Abstract excerpt

Mitochondria are complex organelles that play a central role in metabolism. Dynamic membrane-associated processes regulate mitochondrial morphology and bioenergetics in response to cellular demand. In tumor cells, metabolic reprogramming requires active mitochondrial metabolism for providing key metabolites and building blocks for tumor growth and rapid proliferation. To counter this, the mitochondrial serine beta...

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Literature Corpus work: 3e0dc0b3-3944-5b6f-a0e2-46778b6d41dd
DOI: 10.1101/2022.04.21.489104

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