Article
Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.
JCI insight - 23 Apr 2020
Portelli Michael A, Dijk F Nicole, Ketelaar Maria E, Shrine Nick, Hankinson Jenny, Bhaker Sangita, Grotenboer Néomi S, Obeidat Ma'en, Henry Amanda P, Billington Charlotte K, Shaw Dominick, Johnson Simon R, Pogson Zara Ek, Fogarty Andrew, McKeever Tricia M, Nickle David C, Bossé Yohan, van den Berge Maarten, Faiz Alen, Brouwer Sharon, Vonk Judith M, de Vos Paul, Brandsma Corry-Anke, Vermeulen Cornelis J, Singapuri Amisha, Heaney Liam G, Mansur Adel H, Chaudhuri Rekha, Thomson Neil C, Holloway John W, Lockett Gabrielle A, Howarth Peter H, Niven Robert, Simpson Angela, Blakey John D, Tobin Martin D, Postma Dirkje S, Hall Ian P, Wain Louise V, Nawijn Martijn C, Brightling Christopher E, Koppelman Gerard H, Sayers Ian
Abstract excerpt
The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be defined. We tested for association between IL1RL1 region SNPs and characteristics of asthma as defined by clinical and immunological measures and addressed functional...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.