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Article

IL1RL1 gene variants and nasopharyngeal IL1RL-a levels are associated with severe RSV bronchiolitis: a multicenter cohort study.

PloS one - 1 Jan 2012

Faber Tina E, Schuurhof Annemieke, Vonk Annelies, Koppelman Gerard H, Hennus Marije P, Kimpen Jan L L, Janssen Riny, Bont Louis J

Abstract excerpt

BACKGROUND: Targets for intervention are required for respiratory syncytial virus (RSV) bronchiolitis, a common disease during infancy for which no effective treatment exists. Clinical and genetic studies indicate that IL1RL1 plays an important role in the development and exacerbations of asthma. Human IL1RL1 encodes three isoforms, including soluble IL1RL1-a, that can influence IL33 signalling by modifying...

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Identifiers

PMID: 22574108
DOI: 10.1371/journal.pone.0034364
PMCID: PMC3344820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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