IL1RL1 asthma risk variants regulate airway type 2 inflammation.

doi:10.1172/jci.insight.87871

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Article

IL1RL1 asthma risk variants regulate airway type 2 inflammation.

JCI insight - 8 Sept 2016

Gordon Erin D, Palandra Joe, Wesolowska-Andersen Agata, Ringel Lando, Rios Cydney L, Lachowicz-Scroggins Marrah E, Sharp Louis Z, Everman Jamie L, MacLeod Hannah J, Lee Jae W, Mason Robert J, Matthay Michael A, Sheldon Richard T, Peters Michael C, Nocka Karl H, Fahy John V, Seibold Max A

Abstract excerpt

Genome-wide association studies of asthma have identified genetic variants in the IL1RL1 gene, but the molecular mechanisms conferring risk are unknown. IL1RL1 encodes the ST2 receptor (ST2L) for IL-33 and an inhibitory decoy receptor (sST2). IL-33 promotes type 2 inflammation, which is present in some but not all asthmatics. We find that two single nucleotide polymorphisms (SNPs) in IL1RL1 - rs1420101 and...

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Identifiers

PMID: 27699235
DOI: 10.1172/jci.insight.87871
PMCID: PMC5033813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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