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Article

The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention

2 Apr 2021

Abstract excerpt

Interleukin-33 (IL-33), a member of the IL-1 family, and its cognate receptor, Interleukin-1 receptor like-1 (IL-1RL1 or ST2), are susceptibility genes for childhood asthma. In response to cellular damage, IL-33 is released from barrier tissues as an 'alarmin' to activate the innate immune response. IL-33 drives type 2 responses by inducing signalling through its receptor IL-1RL1 in several immune and structural...

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Identifiers

PMID: 33819560
DOI: 10.1016/j.pharmthera.2021.107847

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