Article
Genetic regulation of IL1RL1 methylation and IL1RL1-a protein levels in asthma.
The European respiratory journal - 1 Mar 2018
Dijk F Nicole, Xu Chengjian, Melén Erik, Carsin Anne-Elie, Kumar Asish, Nolte Ilja M, Gruzieva Olena, Pershagen Goran, Grotenboer Neomi S, Savenije Olga E M, Antó Josep Maria, Lavi Iris, Dobaño Carlota, Bousquet Jean, van der Vlies Pieter, van der Valk Ralf J P, de Jongste Johan C, Nawijn Martijn C, Guerra Stefano, Postma Dirkje S, Koppelman Gerard H
Abstract excerpt
Interleukin-1 receptor-like 1 (IL1RL1) is an important asthma gene. (Epi)genetic regulation of IL1RL1 protein expression has not been established. We assessed the association between IL1RL1 single nucleotide polymorphisms (SNPs), IL1RL1 methylation and serum IL1RL1-a protein levels, and aimed to identify causal pathways in asthma.Associations of IL1RL1 SNPs with asthma were determined in the Dutch Asthma...
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