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Article

Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma.

The Journal of allergy and clinical immunology - 1 Jan 2015

Traister Russell S, Uvalle Crystal E, Hawkins Gregory A, Meyers Deborah A, Bleecker Eugene R, Wenzel Sally E

Abstract excerpt

BACKGROUND: Severe asthma remains poorly characterized, although it likely consists of at least 1 phenotype with features of TH2-like inflammation. IL1RL1, encoding both the IL-33 receptor, ST2L, and decoy receptor, sST2, has been genetically associated with asthma, though the mechanism for susceptibility remains unknown. OBJECTIVE: Given previous data supporting a role for IL1RL1 in TH2 inflammation, we...

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Source

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Identifiers

PMID: 25091434
DOI: 10.1016/j.jaci.2014.06.023
PMCID: PMC4289095

Genes

CLCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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