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Article

Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood.

The Journal of allergy and clinical immunology - 1 Jul 2014

Savenije Olga E, Mahachie John Jestinah M, Granell Raquel, Kerkhof Marjan, Dijk F Nicole, de Jongste Johan C, Smit Henriëtte A, Brunekreef Bert, Postma Dirkje S, Van Steen Kristel, Henderson John, Koppelman Gerard H

Abstract excerpt

BACKGROUND: Genome-wide association studies identified IL33 and IL-1 receptor-like 1 (IL1RL1)/IL18R1 as asthma susceptibility loci. IL33 and IL1RL1 constitute a single ligand-receptor pathway. OBJECTIVE: In 2 birth cohorts, the Prevalence and Incidence of Asthma and Mite Allergy (PIAMA) study and Avon Longitudinal Study of Parents and Children (ALSPAC), we analyzed associations of longitudinal wheezing phenotypes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24568840
DOI: 10.1016/j.jaci.2013.12.1080

Genes

TRAF6
TIRAP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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