Article
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
PloS one - 1 Jan 2012
Ramasamy Adaikalavan, Kuokkanen Mikko, Vedantam Sailaja, Gajdos Zofia K, Couto Alves Alexessander, Lyon Helen N, Ferreira Manuel A R, Strachan David P, Zhao Jing Hua, Abramson Michael J, Brown Matthew A, Coin Lachlan, Dharmage Shyamali C, Duffy David L, Haahtela Tari, Heath Andrew C, Janson Christer, Kähönen Mika, Khaw Kay-Tee, Laitinen Jaana, Le Souef Peter, Lehtimäki Terho, Madden Pamela A F, Marks Guy B, Martin Nicholas G, Matheson Melanie C, Palmer Cameron D, Palotie Aarno, Pouta Anneli, Robertson Colin F, Viikari Jorma, Widen Elisabeth, Wjst Matthias, Jarvis Deborah L, Montgomery Grant W, Thompson Philip J, Wareham Nick, Eriksson Johan, Jousilahti Pekka, Laitinen Tarja, Pekkanen Juha, Raitakari Olli T, O'Connor George T, Salomaa Veikko, Jarvelin Marjo-Riitta, Hirschhorn Joel N
Abstract excerpt
RATIONALE: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies. OBJECTIVES: To test if population-based cohorts with self-reported physician-diagnosed asthma and genome-wide association (GWA) data could be used to validate known associations with asthma and identify novel associations. METHODS: The...
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