Article
Bacterial population kinetics in heteroresistant Mycobacterium tuberculosis harbouring rare resistance-conferring mutations in gyrA and rpoB imply an epistatic interaction of mutations in a pre-XDR-TB patient.
The Journal of antimicrobial chemotherapy - 1 Jul 2020
Yoshida Shiomi, Iwamoto Tomotada, Arikawa Kentaro, Sekizuka Tsuyoshi, Kuroda Makoto, Inoue Yoshikazu, Mitarai Satoshi, Tsuji Taisuke, Tsuyuguchi Kazunari, Suzuki Katsuhiro
Abstract excerpt
OBJECTIVES: Bacterial population kinetics of strains harbouring drug resistance-conferring mutations within a patient often show cryptic resistance in clinical practice. We report a case that showed emergence and dominance of Mycobacterium tuberculosis with uncommon rpoB and gyrA mutations, followed by an rpoC compensatory mutation, during treatment. METHODS: A pre-XDR-TB patient showed heteroresistance to...
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