Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment.

EBioMedicine - 1 May 2020

Nimmo Camus, Brien Kayleen, Millard James, Grant Alison D, Padayatchi Nesri, Pym Alexander S, O'Donnell Max, Goldstein Richard, Breuer Judith, Balloux François

Abstract excerpt

BACKGROUND: Studying within-host genetic diversity of Mycobacterium tuberculosis (Mtb) in patients during treatment may identify adaptations to antibiotic and immune pressure. Understanding the significance of genetic heteroresistance, and more specifically heterozygous resistance-associated variants (RAVs), is clinically important given increasing use of rapid molecular tests and whole genome sequencing (WGS)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diarylquinolines
Share to Fluoroquinolones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metabolic Networks and Pathways

Share to Rifampin

Share to South Africa

Share to Sputum

Share to Tuberculosis, Multidrug-Resistant

Share to Tuberculosis, Pulmonary

Source

Open in PubMed Open full text

Identifiers

PMID: 32361247
DOI: 10.1016/j.ebiom.2020.102747
PMCID: PMC7195533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment.PMID 32361247Read ↗

Dynamics of within-host<i>Mycobacterium tuberculosis</i>diversity and heteroresistance during treatmentSemantic proximity Read ↗

Direct transmission of within-host Mycobacterium tuberculosis diversity to secondary cases can lead to variable between-host heterogeneity without de novo mutation: A genomic investigationSemantic proximity Read ↗

Within-Host Heterogeneity ofMycobacterium tuberculosisInfection Is Associated With Poor Early Treatment Response: A Prospective Cohort StudySemantic proximity Read ↗

Mixed-strain infection and heteroresistance in drug-resistant tuberculosis: insights from a whole-genome sequencing pilotSemantic proximity Read ↗

The within-host evolution of antimicrobial resistance in Mycobacterium tuberculosisSemantic proximity Read ↗

Within-host pathogen population diversity predicts treatment response in TuberculosisSemantic proximity Read ↗

Lesion Heterogeneity and Long-Term Heteroresistance in Multidrug-Resistant Tuberculosis.Semantic proximity Read ↗

In-host population dynamics of Mycobacterium tuberculosis complex during active disease.Semantic proximity Read ↗

Intra-host genetic population diversity: Role in emergence and persistence of drug resistance among Mycobacterium tuberculosis complex minor variants.Semantic proximity Read ↗

Within patient microevolution of Mycobacterium tuberculosis correlates with heterogeneous responses to treatment.Semantic proximity Read ↗

Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment.Semantic proximity Read ↗

The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.