Genetic factors associated with acquired phenotypic drug resistance and its compensatory evolution during tuberculosis treatment.

doi:10.1016/j.cmi.2024.01.016

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Article

Genetic factors associated with acquired phenotypic drug resistance and its compensatory evolution during tuberculosis treatment.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 May 2024

Zhang Guoqin, Sun Xianhui, Fleming Joy, Ran Fanlei, Luo Jianjun, Chen Hong, Ju Hanfang, Wang Zhirui, Zhao Hui, Wang Chunhua, Zhang Fan, Dai Xiaowei, Yang Xinyu, Li Chuanyou, Liu Yi, Wang Yaguo, Zhang Xilin, Jiang Yuan, Wu Zhilong, Bi Lijun, Zhang Hongtai

Abstract excerpt

OBJECTIVES: We elucidated the factors, evolution, and compensation of antimicrobial resistance (AMR) in Mycobacterium tuberculosis (MTB) isolates under dual pressure from the intra-host environment and anti-tuberculosis (anti-TB) drugs. METHODS: This retrospective case-control study included 337 patients with pulmonary tuberculosis from 15 clinics in Tianjin, China, with phenotypic drug susceptibility testing...

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PMID: 38286176
DOI: 10.1016/j.cmi.2024.01.016

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