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Article

The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy.

Genome biology - 19 Apr 2017

Trauner Andrej, Liu Qingyun, Via Laura E, Liu Xin, Ruan Xianglin, Liang Lili, Shi Huimin, Chen Ying, Wang Ziling, Liang Ruixia, Zhang Wei, Wei Wang, Gao Jingcai, Sun Gang, Brites Daniela, England Kathleen, Zhang Guolong, Gagneux Sebastien, Barry Clifton E, Gao Qian

Abstract excerpt

BACKGROUND: Combination therapy is one of the most effective tools for limiting the emergence of drug resistance in pathogens. Despite the widespread adoption of combination therapy across diseases, drug resistance rates continue to rise, leading to failing treatment regimens. The mechanisms underlying treatment failure are well studied, but the processes governing successful combination therapy are poorly...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 28424085
DOI: 10.1186/s13059-017-1196-0
PMCID: PMC5395877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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