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Article

Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment.

The Journal of infectious diseases - 15 Mar 2022

Hjort Karin, Jurén Pontus, Toro Juan Carlos, Hoffner Sven, Andersson Dan I, Sandegren Linus

Abstract excerpt

Mycobacterium tuberculosis is one of the hardest to treat bacterial pathogens with a high capacity to develop antibiotic resistance by mutations. Here we have performed whole-genome sequencing of consecutive M. tuberculosis isolates obtained during 9 years from a patient with pulmonary tuberculosis. The infecting strain was isoniazid resistant and during treatment it stepwise accumulated resistance mutations to 8...

Topics

Antitubercular Agents
Drug Resistance
Drug Resistance, Multiple, Bacterial
Humans
Isoniazid
Microbial Sensitivity Tests
Mutation
Mycobacterium tuberculosis
Tuberculosis
Tuberculosis, Multidrug-Resistant

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Identifiers

PMID: 33045067
DOI: 10.1093/infdis/jiaa625
PMCID: PMC8921999

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