Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients.

The Journal of infectious diseases - 1 Dec 2012

Sun Gang, Luo Tao, Yang Chongguang, Dong Xinran, Li Jing, Zhu Yongqiang, Zheng Huajun, Tian Weidong, Wang Shengyue, Barry Clifton E, Mei Jian, Gao Qian

Abstract excerpt

BACKGROUND: Drug-resistant tuberculosis poses a growing challenge to global public health. However, the diversity and dynamics of the bacterial population during acquisition of drug resistance have yet to be carefully examined. METHODS: Whole-genome sequencing was performed on 7 serial Mycobacterium tuberculosis (M. tuberculosis) populations from 3 patients during different stages in the development of drug...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to Biological Evolution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple, Bacterial

Share to Gene Expression Regulation, Bacterial

Share to Genome, Bacterial

Share to Mycobacterium tuberculosis

Share to Tuberculosis, Multidrug-Resistant

Share to Tuberculosis, Pulmonary

Source

Open in PubMed Open full text

Identifiers

PMID: 22984115
DOI: 10.1093/infdis/jis601
PMCID: PMC3488197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients.PMID 22984115Read ↗

Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment.Semantic proximity Read ↗

In vivo evolution of drug-resistant Mycobacterium tuberculosis in patients during long-term treatment.Semantic proximity Read ↗

Evolution of extensively drug-resistant Mycobacterium tuberculosis from a susceptible ancestor in a single patient.Semantic proximity Read ↗

The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy.Semantic proximity Read ↗

In-host population dynamics of Mycobacterium tuberculosis complex during active disease.Semantic proximity Read ↗

Genetic factors associated with acquired phenotypic drug resistance and its compensatory evolution during tuberculosis treatment.Semantic proximity Read ↗

Signatures of selection at drug resistance loci in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Mutation rate and the emergence of drug resistance in Mycobacterium tuberculosisSemantic proximity Read ↗

A proportion of mutations fixed in the genomes of in vitro selected isogenic drug-resistant Mycobacterium tuberculosis mutants can be detected as minority variants in the parent culture.Semantic proximity Read ↗

Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung EnvironmentSemantic proximity Read ↗

The within-host evolution of antimicrobial resistance in Mycobacterium tuberculosisSemantic proximity Read ↗

Genetic mechanisms of co-emergence of INH-resistant Mycobacterium tuberculosis strains during the standard course of antituberculosis therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.