Article

Polyclonal pathogen populations accelerate the evolution of antibiotic resistance in patients

2021-12-11

Abstract excerpt

Antibiotic resistance poses a global health threat, but the within-host drivers of resistance remain poorly understood. Pathogen populations are often assumed to be clonal within hosts, and resistance is thought to emerge due to selection for de novo variants. Here we show that pulmonary populations of the opportunistic pathogen P. aeruginosa are often polyclonal. Crucially, resistance evolves rapidly in patient...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1789b652-7112-56c8-9f2a-30ffa911395d
DOI: 10.1101/2021.12.10.472119

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polyclonal pathogen populations accelerate the evolution of antibiotic resistance in patientsDOI 10.1101/2021.12.10.472119Read

Multiple ecological and evolutionary mechanisms drive treatment-induced antibiotic resistanceSemantic proximity Read

Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance.Semantic proximity Read

Resistance variation and bacterial interactions shape adaptation of a genetically diverse pathogen population to antibiotic therapy.Semantic proximity Read

Within-Patient Evolution of <i>Pseudomonas aeruginosa</i> Populations During Antimicrobial TreatmentSemantic proximity Read

Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections.Semantic proximity Read

Hypermutator <i>Pseudomonas aeruginosa</i> exploits multiple genetic pathways to develop multidrug resistance during long-term infections in the airways of cystic fibrosis patientsSemantic proximity Read

Within-patient evolution of Pseudomonas aeruginosa populations during antimicrobial treatment.Semantic proximity Read

Resistance variation and bacterial interactions shape the adaptation of a genetically diverse bacterial population to antimicrobial treatmentSemantic proximity Read

Cryptic Evolution of Heteroresistance as Adaptation to Treatment InterruptionsSemantic proximity Read

Public health evolutionary biology of antimicrobial resistance: priorities for interventionSemantic proximity Read

Hypermutator Pseudomonas aeruginosa Exploits Multiple Genetic Pathways To Develop Multidrug Resistance during Long-Term Infections in the Airways of Cystic Fibrosis Patients.Semantic proximity Read

From Petri Dishes to Patients to Populations: Scales and Evolutionary Mechanisms Driving Antibiotic ResistanceSemantic proximity Read