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Article

Cortical microstructural correlates of astrocytosis in autosomal-dominant Alzheimer disease.

Neurology - 12 May 2020

Vilaplana Eduard, Rodriguez-Vieitez Elena, Ferreira Daniel, Montal Victor, Almkvist Ove, Wall Anders, Lleó Alberto, Westman Eric, Graff Caroline, Fortea Juan, Nordberg Agneta

Abstract excerpt

OBJECTIVE: To study the macrostructural and microstructural MRI correlates of brain astrocytosis, measured with 11C-deuterium-L-deprenyl (11C-DED)-PET, in familial autosomal-dominant Alzheimer disease (ADAD). METHODS: The total sample (n = 31) comprised ADAD mutation carriers (n = 10 presymptomatic, 39.2 ± 10.6 years old; n = 3 symptomatic, 55.5 ± 2.0 years old) and noncarriers (n = 18, 44.0 ± 13.7 years old)...

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Identifiers

PMID: 32291295
DOI: 10.1212/WNL.0000000000009405
PMCID: PMC7282881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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