Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease.

doi:10.1002/alz.12224

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Article

Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2021

Montal Victor, Vilaplana Eduard, Pegueroles Jordi, Bejanin Alexandre, Alcolea Daniel, Carmona-Iragui María, Clarimón Jordi, Levin Johannes, Cruchaga Carlos, Graff-Radford Neill R, Noble James M, Lee Jae-Hong, Allegri Ricardo, Karch Celeste M, Laske Christoph, Schofield Peter R, Salloway Stephen, Ances Beau, Benzinger Tammie, McDale Eric, Bateman Randall, Blesa Rafael, Sánchez-Valle Raquel, Lleó Alberto, Fortea Juan

Abstract excerpt

INTRODUCTION: A biphasic model for brain structural changes in preclinical Alzheimer's disease (AD) could reconcile some conflicting and paradoxical findings in observational studies and anti-amyloid clinical trials. METHODS: In this study we tested this model fitting linear versus quadratic trajectories and computed the timing of the inflection points vertexwise of cortical thickness and cortical diffusivity-a...

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PMID: 33196147
DOI: 10.1002/alz.12224
PMCID: PMC8043974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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