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Article

Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study.

European journal of nuclear medicine and molecular imaging - 1 Jun 2015

Rodriguez-Vieitez Elena, Ni Ruiqing, Gulyás Balázs, Tóth Miklós, Häggkvist Jenny, Halldin Christer, Voytenko Larysa, Marutle Amelia, Nordberg Agneta

Abstract excerpt

PURPOSE: Pathological studies suggest that neuroinflammation is exacerbated by increased beta-amyloid (Aβ) levels in the brain early in Alzheimer's disease (AD). The time course and relationships between astrocytosis and Aβ deposition were examined using multitracer in vivo positron emission tomography (PET) imaging in an AD transgenic mouse model, followed by postmortem autoradiography and immunohistochemistry...

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Identifiers

PMID: 25893384
DOI: 10.1007/s00259-015-3047-0
PMCID: PMC4424277

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GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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