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Article

Early functional changes and plasma GFAP in Swedish families with Autosomal Dominant Alzheimer's disease mutations.

Translational psychiatry - 27 Jan 2026

Luckett Emma S, Zapater-Fajari Mariola, Almkvist Ove, Johansson Charlotte, Chiotis Konstantinos, Bucci Marco, Wall Anders, Ashton Nicholas J, Blennow Kaj, Zetterberg Henrik, Rodriguez-Vieitez Elena, Graff Caroline, Nordberg Agneta

Abstract excerpt

We aimed to understand longitudinal associations between Alzheimer's disease (AD) biomarkers in Autosomal Dominant AD (ADAD) across estimated years to symptom onset (EYO). Forty-five individuals (19 mutation carriers [EYO = -7.9 ± 11.7 years, APP N = 11; PSEN1 N = 8]) from Swedish ADAD families participated. All received baseline 18F-Flurodeoxyglucose (FDG) PET and cognitive testing, and a subset (N = 26) plasma...

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Identifiers

PMID: 41593046
DOI: 10.1038/s41398-026-03829-6
PMCID: PMC12877000

Genes

APP
GFAP
PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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