Article

Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease

2022-01-29

Abstract excerpt

Astrocytes can adopt multiple molecular phenotypes in the brain of Alzheimer’s disease (AD) patients. Here, we studied the associations of cerebrospinal fluid (CSF) glial fibrillary acidic protein (GFAP) and chitinase-3-like protein 1 (YKL-40) levels with brain amyloid-β (Aβ) and tau pathologies. We assessed 121 individuals across the aging and AD clinical spectrum with positron emission tomography (PET) brain ima...

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Literature Corpus work: 1e4f7df3-8ddd-596f-a145-1fbeb16a267c
DOI: 10.1101/2022.01.25.22269841

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