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Histologically validated diffusion MRI signatures of neuroinflammation and neurodegeneration in Alzheimer disease

2026-06-22

Abstract excerpt

Noninvasive neuroinflammation measurement remains a major barrier for Alzheimer disease (AD) therapeutics. We present generalized diffusion basis spectrum imaging (g-DBSI), a diffusion MRI framework that decomposes the tissue signal into biologically interpretable microstructural compartments. In postmortem Knight ADRC brains, g-DBSI-derived restricted isotropic fraction (RIF) and restricted anisotropic fraction (...

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Literature Corpus work
a4487fec-e84f-5f40-99a2-b19fd078aa54
DOI
10.64898/2026.06.11.26354743
Open publication

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