Article
Mutational heterogeneity between different regional tumour grades of clear cell renal cell carcinoma.
Experimental and molecular pathology - 1 Aug 2020
Ferronika Paranita, Kats-Ugurlu Gursah, Haryana Sofia M, Utoro Totok, Rinonce Hanggoro Tri, Danarto Raden, de Lange Kim, Terpstra Martijn M, Sijmons Rolf H, Westers Helga, Kok Klaas
Abstract excerpt
Only a limited number of studies have explored the possible associations between tumour grade and mutated genes in clear cell renal cell carcinoma (ccRCC), and we set out to investigate this further using a multiple sampling and next generation sequencing (NGS) approach in a series of ccRCCs. Multiple regions were sampled from formalin-fixated paraffin-embedded ccRCC tumour blocks from seven patients. In 27...
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