Article
Systematic evaluation of the prognostic impact and intratumour heterogeneity of clear cell renal cell carcinoma biomarkers.
European urology - 1 Nov 2014
Gulati Sakshi, Martinez Pierre, Joshi Tejal, Birkbak Nicolai Juul, Santos Claudio R, Rowan Andrew J, Pickering Lisa, Gore Martin, Larkin James, Szallasi Zoltan, Bates Paul A, Swanton Charles, Gerlinger Marco
Abstract excerpt
BACKGROUND: Candidate biomarkers have been identified for clear cell renal cell carcinoma (ccRCC) patients, but most have not been validated. OBJECTIVE: To validate published ccRCC prognostic biomarkers in an independent patient cohort and to assess intratumour heterogeneity (ITH) of the most promising markers to guide biomarker optimisation. DESIGN, SETTING, AND PARTICIPANTS: Cancer-specific survival (CSS) for...
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