Article
Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma.
Nature communications - 15 Jul 2024
Culliford Richard, Lawrence Samuel E D, Mills Charlie, Tippu Zayd, Chubb Daniel, Cornish Alex J, Browning Lisa, Kinnersley Ben, Bentham Robert, Sud Amit, Pallikonda Husayn, Frangou Anna, Gruber Andreas J, Litchfield Kevin, Wedge David, Larkin James, Turajlic Samra, Houlston Richard S
Abstract excerpt
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer, but a comprehensive description of its genomic landscape is lacking. We report the whole genome sequencing of 778 ccRCC patients enrolled in the 100,000 Genomes Project, providing for a detailed description of the somatic mutational landscape of ccRCC. We identify candidate driver genes, which as well as emphasising the major role...
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