Article

Spatial distribution of private gene mutations in clear cell renal cell carcinoma

2018-04-20

Abstract excerpt

Intra-tumour heterogeneity is the molecular hallmark of renal cancer, and the molecular tumour composition determines the treatment outcome of renal cancer patients. In renal cancer tumourigenesis, in general, different tumour clones evolve over time. We analysed intra-tumour heterogeneity and subclonal mutation patterns in 178 tumour samples obtained from 89 clear cell renal cell carcinoma patients. In an initial...

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Literature Corpus work: 49a71bde-bfd4-5282-86b5-aa7cdf0ed093
DOI: 10.1101/305623

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