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Article

Risk HLA-DRB1 alleles differentially influence brain and lesion volumes in Japanese patients with multiple sclerosis.

Journal of the neurological sciences - 15 Jun 2020

Fukumoto Shoko, Nakamura Yuri, Watanabe Mitsuru, Isobe Noriko, Matsushita Takuya, Sakoda Ayako, Hiwatashi Akio, Shinoda Koji, Yamasaki Ryo, Tsujino Akira, Kira Jun-Ichi

Abstract excerpt

BACKGROUND: The effects of distinct HLA alleles on the brain and lesion volumes remain to be established, particularly in non-Caucasian populations. Two distinct susceptibility alleles, DRB1*15:01 and DRB1*04:05, are prevalent in the Japanese population; we therefore aimed to clarify the effects of HLA-DRB1 alleles on brain and lesion volumes in multiple sclerosis (MS). METHODS: A total of 66 patients with MS (50...

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PMID: 32247967
DOI: 10.1016/j.jns.2020.116768

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