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Article

Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures.

Brain : a journal of neurology - 1 Jan 2009

Okuda D T, Srinivasan R, Oksenberg J R, Goodin D S, Baranzini S E, Beheshtian A, Waubant E, Zamvil S S, Leppert D, Qualley P, Lincoln R, Gomez R, Caillier S, George M, Wang J, Nelson S J, Cree B A C, Hauser S L, Pelletier D

Abstract excerpt

Genetic susceptibility to multiple sclerosis (MS) is associated with the human leukocyte antigen (HLA) DRB1*1501 allele. Here we show a clear association between DRB1*1501 carrier status and four domains of disease severity in an investigation of genotype-phenotype associations in 505 robust, clinically well characterized MS patients evaluated cross-sectionally: (i) a reduction in the N-acetyl-aspartate (NAA)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19022862
DOI: 10.1093/brain/awn301
PMCID: PMC2638695

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