Article
Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis.
JAMA neurology - 1 Jul 2016
Isobe Noriko, Keshavan Anisha, Gourraud Pierre-Antoine, Zhu Alyssa H, Datta Esha, Schlaeger Regina, Caillier Stacy J, Santaniello Adam, Lizée Antoine, Himmelstein Daniel S, Baranzini Sergio E, Hollenbach Jill, Cree Bruce A C, Hauser Stephen L, Oksenberg Jorge R, Henry Roland G
Abstract excerpt
IMPORTANCE: Although multiple HLA alleles associated with multiple sclerosis (MS) risk have been identified, genotype-phenotype studies in the HLA region remain scarce and inconclusive. OBJECTIVES: To investigate whether MS risk-associated HLA alleles also affect disease phenotypes. DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional, case-control study comprising 652 patients with MS who had comprehensive...
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