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Article

Heterogeneity at the HLA-DRB1 allelic variation locus does not influence multiple sclerosis disease severity, brain atrophy or cognition.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Mar 2011

Van der Walt Anneke, Stankovich J, Bahlo M, Taylor B V, Van der Mei I A F, Foote S J, Rubio J P, Kilpatrick T J, Butzkueven H

Abstract excerpt

BACKGROUND: HLA-DRB1*1501 (DR15) and other HLA class II alleles increase the risk of developing multiple sclerosis (MS). However, the contribution of genetic heterogeneity to the clinical course of MS remains controversial. We examined the influence of DR15 and other common DRB1 alleles (DRB1*01 (DR1), DRB1*03 (DR3) and DRB1*04 (DR4) on MS severity in a large, Australian, population-based cohort. METHODS: We...

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PMID: 21149397
DOI: 10.1177/1352458510389101

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