Article
HLA-DRB1*04:05 allele is associated with intracortical lesions on three-dimensional double inversion recovery images in Japanese patients with multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 May 2018
Shinoda Koji, Matsushita Takuya, Nakamura Yuri, Masaki Katsuhisa, Yamasaki Ryo, Yamaguchi Hiroo, Togao Osamu, Hiwatashi Akio, Kira Jun-Ichi
Abstract excerpt
BACKGROUND: Cortical lesions (CLs) frequently observed in Caucasian patients with multiple sclerosis (MS) contribute to disability. However, it remains unclear whether CLs are associated with clinical features and genetic risk factors, such as HLA-DRB1*15:01 and -DRB1*04:05 in Asian MS patients. OBJECTIVE: To elucidate the frequency of CLs and their association with HLA-DRB1 and DPB1 alleles in Japanese MS...
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