Disease-Associated HLA Alleles and Haplotypes in Multiple Sclerosis: Insights from an Albanian Case–Control Study

Abstract excerpt

<h4>Background</h4> Multiple sclerosis (MS) is a complex autoimmune disease with the HLA region showing the strongest known genetic influence. Although HLA-DRB1*15:01 is a well-known risk allele in European populations, data from Southeastern Europe—and Albania specifically—are still limited. <h4>Objective</h4> To assess allele- and haplotype-level associations at HLA class I (A*, B*, C*) and class II (DRB1*, DQ...

Topics

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• Alleles
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Histocompatibility Testing
• HLA-DQ beta-Chains
• HLA-DRB1 Chains
• Multiple Sclerosis
• Risk Factors

Identifiers and source

Literature Corpus work

982b8541-a360-5f8e-8753-4bb073b008a8

DOI

10.64898/2025.12.01.25341397