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Article

CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia

14 May 2018

Abstract excerpt

locus reduced human leukemic blast burden and enhanced survival of transplanted AML cell xenograft and patient-derived xenograft mouse models. Thus, the CTCF boundary constrains the normal gene-expression program, as well as plays a role in maintaining the oncogenic transcription program for leukemic transformation. The CTCF boundaries may serve as novel therapeutic targets for the treatment of myeloid malignancies.

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Identifiers

PMID: 29760161
DOI: 10.1182/blood-2017-11-814319

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