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Article

DNA methylation disruption reshapes the hematopoietic differentiation landscape.

Nature genetics - 1 Apr 2020

Izzo Franco, Lee Stanley C, Poran Asaf, Chaligne Ronan, Gaiti Federico, Gross Baptiste, Murali Rekha R, Deochand Sunil D, Ang Chelston, Jones Philippa Wyndham, Nam Anna S, Kim Kyu-Tae, Kothen-Hill Steven, Schulman Rafael C, Ki Michelle, Lhoumaud Priscillia, Skok Jane A, Viny Aaron D, Levine Ross L, Kenigsberg Ephraim, Abdel-Wahab Omar, Landau Dan A

Abstract excerpt

Mutations in genes involved in DNA methylation (DNAme; for example, TET2 and DNMT3A) are frequently observed in hematological malignancies1-3 and clonal hematopoiesis4,5. Applying single-cell sequencing to murine hematopoietic stem and progenitor cells, we observed that these mutations disrupt hematopoietic differentiation, causing opposite shifts in the frequencies of erythroid versus myelomonocytic progenitors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32203468
DOI: 10.1038/s41588-020-0595-4
PMCID: PMC7216752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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