Article

Epigenome-wide DNA Methylation Association Study of CHIP Provides Insight into Perturbed Gene Regulation

2024-07-16

Abstract excerpt

<title>Abstract</title> <p>With age, hematopoietic stem cells can acquire somatic mutations in leukemogenic genes that confer a proliferative advantage in a phenomenon termed “clonal hematopoiesis of indeterminate potential” (CHIP). How these mutations confer a proliferative advantage and result in increased risk for numerous age-related diseases remains poorly understood. We conducted a multiracial meta-analysis...

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Literature Corpus work: c2709652-08cc-5330-aa2b-9b7450556625
DOI: 10.21203/rs.3.rs-4656898/v1

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